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Download DemoVendor: USMLE
Certifications: USMLE Certifications
Exam Code: USMLE-STEP-2
Exam Name: United States Medical Licensing Step 2
Updated: Nov 27, 2024
Q&As: 738
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A 46-year-old G3P3 woman has had postcoital spotting for 6 months. On pelvic examination, she has a fungating, exophytic lesion arising from her cervix that is approximately 2 cm in diameter. Biopsy of this lesion is interpreted as invasive squamous cell carcinoma of the cervix. There is no evidence of extension of the cancer onto the vagina. The parametria are indurated on bimanual examination, though not to the pelvic sidewall. CT scan of her pelvis and abdomen discloses enlarged paraaortic lymph nodes and metastatic lesions in the parenchyma of her liver. This woman's childbearing is complete. She is a healthy woman who is close to ideal body weight, exercises regularly, and does not smoke. Which of the following is the most appropriate treatment of this woman?
A. TAH-BSO
B. radical hysterectomy with pelvic and paraaortic lymph node dissection
C. pelvic exenteration
D. multiagent chemotherapy
E. combined brachytherapy and external radiation therapy
Correct Answer: E
Although this 46-year-old woman is staged as a IIB, she should be treated as a stage IVBbecause of the findings on CT scan. Methods of staging that are similar allow institutions to compare results of treatment without having to account for different staging procedures and criteria. Asimple TAH-BSO is appropriate therapy only for women with carcinoma in situ of the cervix (CIN III, stage 0). Women with stage I or IIA may be treated with radical hysterectomy or with radiation therapy. Beyond stage IIA, only radiation therapy is acceptable. A pelvic exenteration is indicated when there is a central recurrence after maximal dose radiation therapy. Platinum-based chemotherapy has been used for women with metastases or recurrence after radiation therapy. It is considered palliative. Also, some suggest that a lymphadenectomy be performed before the start of radiation. Recently, several have used chemotherapy as primary therapy for bulk disease. There are no randomized-controlled trials to document that chemotherapy is superior to surgery or radiation.
A 16-year-old girl presents because she has not begun to menstruate. Also, breast development and pubic hair have not developed. She is 59 in. (150 cm) tall and weighs 115 lbs (52 kg). On examination, her vital signs are normal. She has skin folds on the lateral sides of her neck. She has evidence of cubitus valgus. Breasts are Tanner stage 1 and the nipples appear to be spaced wider than average. Pubic hair is Tanner stage 1. The external genitalia are normal. The vagina is of normal depth and a small cervix is seen on speculum examination. The uterus is present but small. There are no adnexal masses.
What is the most likely karyotype of this 16 year old?
A. 46,XX
B. 46,XY
C. 45,X
D. 47,XX trisomy 21
E. 47,XXY
Correct Answer: C
The short stature and other features of Turner syndrome are strong presumptive evidence of a 45,X karyotype. A46,XX and a 46,XY karyotype may be found in women with gonadal dysgenesis. Their clinical presentation is absence of pubertal events, but lack of the physical features of Turner syndrome. Most helpful in excluding either of these karyotypes is the short stature: those with 46,XX or 46,XY gonadal dysgenesis are of normal height. There is nothing in the clinical presentation to suggest 47,XX trisomy 21. The phenotype of those with a 47,XXY karyotype is male, Klinefelter syndrome.
For each of the following scenarios, select the gas exposure responsible for the signs and symptoms.
A sewer worker has acute onset of nausea, headache, and shortness of breath, and has anosmia.
A. carbon monoxide
B. methane
C. hydrogen sulfide
D. ozone
E. sulfur dioxide
Correct Answer: C
Hydrogen sulfide is a colorless gas that rapidly paralyzes the nasal receptors, and is found in sewers. Hydrogen sulfide produces nausea, headache, and shortness of breath. Because it paralyzes the nasal receptors at a concentration of 150 ppm and cannot be smelled shortly after exposure, it is highly dangerous, with instant death from a concentration as low as 1000 ppm.
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